Reviewed by Dr. Chad Gilliam PA

Reading time: three minutes

Managing weight can be challenging, and many adults find it difficult to achieve lasting results with lifestyle changes alone. In fact, 40.3% of U.S. adults are living with obesity (CDC), a condition that increases the risk of heart disease, type 2 diabetes, and other health concerns.

For individuals who qualify, FDA-approved weight loss medications such as Contrave or weekly weight loss injections may offer additional support for long-term weight management.

Key Takeaway

Contrave works by reducing food cravings through a combination of medications that act on the brain. Weekly weight loss injections mimic natural gut hormones to regulate appetite, improve blood sugar control, and support lasting weight loss. Both can be effective when paired with lifestyle modification, including diet, exercise, and behavior change.

What Is Contrave?

Contrave is an oral prescription weight loss medication that combines two drugs: naltrexone and bupropion.

Bupropion affects neurotransmitters to reduce appetite, while naltrexone helps control cravings and the brain’s reward system. Together, they encourage reduced food intake and support gradual weight loss.

Effectiveness

According to data from Contrave, participants using this medication lost an average of 5.4% of their starting body weight when combined with diet and exercise

Side Effects

The most common side effects include nausea, constipation, headache, and sleep disturbances. Other possible effects include dry mouth, dizziness, or increased blood pressure. Regular monitoring with your provider is important while taking this medication.

What Are Weight Loss Injections?

Weight loss injections are prescription treatments designed to help regulate appetite and support metabolism. When combined with healthy lifestyle changes, they make it easier to lose weight and maintain results over time. These injections are typically given once a week under medical supervision as part of a personalized weight management program.

These injections slow stomach emptying, reduce hunger, and increase feelings of fullness. They also improve insulin sensitivity and blood sugar regulation, making them beneficial for individuals with type 2 diabetes and weight concerns.

Effectiveness

Clinical studies show that these medications can help patients lose a significant percentage of their body weight when combined with diet and lifestyle modification. Many individuals achieve weight loss of 10–15% of their starting body weight, with sustained results over time.

Side Effects

The most common side effects are mild gastrointestinal issues such as nausea, diarrhea, or constipation. These typically improve after the first few weeks. Your provider may also monitor heart rate and blood pressure during treatment.

Contrave vs Weight Loss Injections: What to Consider

Deciding between these medications involves looking at more than just weight loss results. Factors like convenience, health history, and cost all play a role in finding the best fit.

Your Commitment

Contrave is taken as a pill twice daily, while weight loss injections are given once a week. Consider which routine best fits your lifestyle and which option you are more likely to maintain over time.

Your Health

Certain conditions, such as seizure disorders, liver concerns, or heart disease, may make one option more suitable than the other. A full medical evaluation is necessary before starting either treatment.

Cost and Coverage

Contrave is available in generic form, which may make it more affordable. Weight loss injections are newer and can be more costly, though insurance coverage is improving. Always check with your provider and insurance company to compare options.

The Role of Lifestyle Modification

Both options are most effective when paired with lifestyle changes. This includes:

  • A reduced-calorie diet
  • Increased physical activity
  • Behavioral support and counseling

Medication can provide the boost you need, but long-term success relies on sustainable lifestyle intervention.

Medical Weight Loss in Madison, AL

Are you ready to take control of your health? At Madison Wellness & Aesthetic Center, we specialize in safe, medically supervised weight loss programs that support long-term results.

To book an appointment at our wellness center in Madison, AL, call (256) 248-9199 or visit us at 844 Slaughter Rd. Suite A, Madison, AL.

FAQs

Who is a good candidate for Contrave?

Adults with a body mass index (BMI) of 30 or higher, or 27 or higher with weight-related health concerns such as type 2 diabetes or heart disease, may qualify for Contrave. A healthcare provider will review your overall health to determine if this medication is appropriate for you.

How much weight can I expect to lose?

Results vary, but studies show Contrave users lose an average of 5–10% of their starting body weight. Weight loss injections have shown average losses of 10% or more when combined with diet and lifestyle changes.

Are these medications safe for long-term use?

Both medications are FDA-approved for chronic weight management. However, ongoing monitoring with your provider is important to ensure safety and effectiveness.

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